key to cancer spread found

Researchers have found a specific protein that switches on the process that releases cancer cells from the creative tumour and allows the cells to spread & expand into new tumours in other parts of the body.

Boffins reported the discovery of disabled-2 (Dab2) in Nature Cell Biology. The work called epithelial-mesenchymal transdifferientiation (EMT) has been identified to play a role in releasing cells on the outside of the solid tumor and transforming them into transient mesenchymal cell: cells with the capability to start to grow a new tumour.

This is regularly the fatal process in breast, ovarian, pancreatic and colon-rectal cancers. Searching to understand how the EMT process begins, Ge Jin, who has combined appointments by the Case Western Reserve University School of Dental Medicine and the Lerner Research Institute at the Cleveland Clinic, began by running backwards from EMT to find its trigger.

The researchers found that a compound called transforming development factor-ß triggers the formation of the Dab2 protein. It was this protein, Dab2 that activated the EMT procedure. He exposed that when the researchers knocked out Dab2, EMT was not triggered. "This is the main piece in cancer investigate that has been missing," Jin said.

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